PPT-In summary, three factors affect the competition between su

Factor 1 Base strength of the nucleophile Weak bases substitution more likely H 2 O ROH PR 3 halides RS N 3 NC RCOO H 2 O and ROH do not react with simple

haloalkanes strong sterically bases strong haloalkanes bases sterically primary react substitution elimination products secondary hindered unhindered nucleophiles factor base

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