PPT-Genetics for Imagers: How Geneticists Model Quantitative Phenotypes

Nelson Freimer UCLA Center for Neurobehavioral Genetics What makes a genetic association significant Outline The problem of achieving validated findings in psychiatric genetics Approaches to genetic mapping and statistical significance. Chapter QUANTITATIVE GENETICS: MEASURING HERITABILITYIntroductiondemonstrations that traits which are normally distributed can arise from the action ofmultiple genes, each with relatively small effect E.g., the evolution of pepper spiciness. …. What does natural selection “act on”?. the . gene. the . individual. the . population. or . group. the . species. They are in you and me; they created us, body and mind; and their preservation is the ultimate rationale for our existence. They have come a long way, those replicators. Now they go by the name of genes, and we are their survival machines.. Selects Five Geneticists to Receive Society’s 2014 Awards Frederick Ausubel receives Thomas Hunt Morgan Medal for lifetime achievement BETHESDA, MD – January 2 9 , 2014 – The G Dr. Andrea . Abbas. . aabbas@lincoln.ac.uk. Dr Julian . Beckton. jbeckton@lincoln.ac.uk. Aims of Session. To consider what counts as acceptable qualitative and quantitative research in different disciplines (similarities and differences) and reflect on how you currently position yourselves. Phenotypes and Endotypes of Uncontrolled Severe Asthma: New Treatments AbstractSevere asthma is a heterogeneous disease that affects only 5%-10% of asthmatic patients, although it accounts for a signi National Academies . NorthStar. Summer Institute for Undergraduate Science Education. Summer 2012. Note that the photos and diagrams in this presentation were acquired from various sources and there may be copyright issues with them.. Rules of Inheritance. Some traits follow the simple rules of . Mendelian. inheritance of dominant and recessive genes.. Complex traits follow different patterns of inheritance that may involve multiple genes and other factors. For example:. Create a Venn diagram comparing phenotype and genotype: Use the . words physical appearance, genetic makeup, heterozygous, homozygous, describes an organism, purple, tall, Pp, green,pp. Describe the difference between complete dominance, incomplete dominance, and codominance. Create a Venn diagram comparing phenotype and genotype: Use the . words physical appearance, genetic makeup, heterozygous, homozygous, describes an organism, purple, tall, Pp, green,pp. Describe the difference between complete dominance, incomplete dominance, and codominance. How are traits passed down from parents to offspring?. Concept 1. : Analyzing the effects of classic . Mendelian. genetic crosses such as . monohybrid, . dihybrid. , testcross. , and applying to . pedigree.  . IB Biology SFP - Mark Polko. 1. 2. IB Biology SFP - Mark Polko. ASSESSMENT STATEMENTS. 3. IB Biology SFP - Mark Polko. 4.3.1 Define . genotype. , . phenotype. , d. ominant allele. , . recessive allele. quali. . tative. traits are the classical Mendelian traits of kinds such as form (e.g., round or wrinkled seeds of pea); structure e.g., horned or hornless condition in . cattles. ) ; pigments (. e.g.,black. Madhan Kumar MD. 1,4. , . Shuizi. Ding. 2. , . Kaiyue. Ma. 2. , . Monkol. Lek PhD. 2. , Donald C. Vinh MD. 1,4. , Marianna M. Henry MD, MPH. 3. , Michael R. Knowles MD. 3,4. , . Maimoona. A. . Zariwala. Zuckerberg San Francisco General. University of California, San Francisco. September 30,20116. Disclosures. Spouse employee of Roche/Genentech. Learning Objectives. Evaluate the concept that asthma is not a single disease.