PPT-13.3- The Human Genome What is a genome?

Genome the total number of genes in an individual Human Genome approx 20000 genes on the 46 human chromosomes Human Genome Project HGP Ongoing effort to completely map and sequence our genome. from Biological . Problem to . Combinatorial Algorithms. (and back). Pavel Pevzner. Department of Computer . Science,. . University . of California at San Diego. What is the evolutionary scenario for transforming one genome into the other?. Genome sequencing. Next Gen sequencing. Genomics = resources. genome maps. genome sequences. genome clones. DNA microarrays. whole gene collections. functional genomics!. 1980- 1998. 1977- 2003. DNA mapping. Active Roles in Evolution of . Immunity and Pregnancy . Retroviruses 2015. Chicago, June 8, 2015. James A. Shapiro. University of . Chicago. jsha@uchicago.edu. www.shapiro.bsd.uchicago.edu. . Evolutionary time: Genome writing . Dan Gilchrist. National Human Genome Research Institute. October 18, 2016. The ENCODE Project. 3D Data Access Through the ENCODE Portal. The ENCODE Encyclopedia. Tools for Investigating Genetic Variants. Venessa. Williams. Hai Tran. Myles Everett. Alex . Detlefsen. Bio 1510-A Group A39. September 13, 2012. Introduction. Little known about genome sequences of Africans. Common ancestors. 1000 Genomes Project used new technology to view whole genome sequences. (before and after 2015). Second International Summit on Human Genome Editing . The University of Hong Kong . November 27-29 2018 . India specific Actions . And Advisory Options Related Human Genome Editing. tens of thousands of DNA bases in length. Fugu is thedraft sequenced after human. Its compact form and sim-sequence. We now have in hand the basic gene-leveldescription of two vertebrates. Compari tens of thousands of DNA bases in length Fugu is thedraft sequenced after human Its compact form and sim-sequence We now have in hand the basic gene-leveldescription of two vertebrates Comparing a Kate R. Rosenbloom, Hiram Clawson, Mark Diekhans, Luvina Guruvadoo, Rachel A. Harte. 1,2. , Donna Karolchik, Brian T. Lee, Brian J. Raney, Ann S. Zweig, . David Haussler. 1,3. , Robert M. Kuhn, W. James Kent. . In the paper, researchers describe the final product of the Human Genome Project, which was the 13year effort to read the information encoded in the human chromosomes that reached its culmination i 1866 Gregor Mendel, an Austrian monk, described basic elements of heredity(these are now called genes). 1860's Friedrich Miescher, a Swiss chemist, did research on the chemical composition of white bl Genomics and Society Nature (2014) “ …disorders not readily explained by standard tests can sometimes be diagnosed through genome sequencing and analysis.” The Origin of “Genomics& INT. J. DIAB. DEV. COUNTRIES (2000), VOL. 20 147Proteinomics Attempts are on to identify the exact three -dimensional structures of nearly 10,000, biologically important, proteins. These are the logic Fahad Alqahtani and Ion Mandoiu. University of Connecticut. Computer Science and Engineering Department. Outline. Introduction & prior . w. ork. Our approach. Preliminary results. Conclusion and future work.