PPT-Evidence-Based Practices for Hereditary Breast and Ovarian Cancer Syndrome and Lynch

Template Slide Set 1 Overview What are Hereditary Breast and Ovarian Cancer syndrome HBOC and Lynch s yndrome LS How common are LS and HBOC How do LS and HBOC affect individuals and families. Raymond Kim. MD/PhD, FRCPC, FCCMG, FACMG. Medical Geneticist. Princess Margaret Cancer Centre. Outline. Genetic terminology and concepts. Hereditary cancers. When to consider. Genetics assessment. Surveillance. Kayla York, MS, LCGC. Licensed Genetic Counselor. Avera Cancer Institute. Outline . Genetic Counseling. Cancer Genetics. Breast/Ovarian Cancer. Colon/Endometrial Cancer . Summary. Genetic Counseling. May 19, 2017. Hereditary Cancer Syndromes. Recognition. , . Testing and . Management. . Disclosures. Nothing to disclose. Objectives. Recognize . patterns of hereditary cancer syndromes and identify appropriate patients for referral . BRCA1 and BRCA2. Jennifer . Hardee. Normal function of the genes. BRCA1 & BRCA2 are in the same DNA repair pathway. Despite names, do not share any protein structure. Both are . tumor suppressors . BRCA1 and BRCA2. Jennifer . Hardee. Normal function of the genes. BRCA1 & BRCA2 are in the same DNA repair pathway. Despite names, do not share any protein structure. Both are . tumor suppressors . Prostate cancer is the most common cancer in males Most men develop prostate cancer by chance or as a result of risk factors that occur over the course ofa lifetime However approximately 10percentof m UterineCancerMost people develop uterine cancer by chance or as a result of risk factors that occur over the course of a lifetime However up to 10percentof people who are diagnosed with uterine cancer Several of my aunts died of breast cancer, so I was very worried when I was diagnosed with breast cancer at age 42. When I talked about my family health history with my doctor, he was also concerned and referred me to a geneticist. I decided to undergo genetic testing for a BRCA mutation. When I tested positive, I was surprised. None of my other family members ever talked about Hereditary Breast and Ovarian Cancer syndrome or my increased risk due to our family history. Knowing that I have a BRCA mutation is powerful information that I will definitely share with others in my family.. Tristan Snowsill. Test Club 5. th. December 2017. Lynch syndrome. Heritable. . cancer syndrome. Heritable. Caused by constitutional mutations affecting the DNA mismatch repair genes . MLH1. , . MSH2. Relatives should be on the same side of the family (first-degree relatives) ie. Parents, sibs, children (second-degree relatives) ie. Grandparents, aunts, uncles, grandchildren er, ovarian cancer Uterine Cancer Most people develop uterine cancer by chance or as a result of risk factors that occur over the course of a lifetime. However, up to 10 % ( percent ) of people who are diagnosed with tiple family members with breast cancer, ovarian cancer, or both. Based on the contemporary understanding of the screening and prevention strategies can be instituted to reduce their risks. Obstetrici Sarah John and Siobhan John SW Nurse facilitators. Why . worry about Lynch?. Each year, 1,100 colorectal cancers are caused by Lynch syndrome, making it the most common form of hereditary colorectal cancer. . Sarah John and Siobhan John . SWGMSA Nurse facilitators. Why . worry about Lynch?. A. t least 260 endometrial cancers are caused by Lynch syndrome. each year . (The Eve Appeal). More than half of women with .