PPT-CPG No. & Name Presenter

Department Insert CPG Name amp Number Background Provide a brief historybackground of the guideline in an effort inform the Internal Control Committee members of the topic Discuss what lead to the modification add delete or modify. G+. T+. A-. C-. G-. T-. A modeling Example. CpG islands in DNA sequences. Methylation & Silencing. One way cells differentiate is methylation. Addition of CH. 3. in C-nucleotides. Silences genes in region. Promoter regions. Mcpt1 (606bp). Nts. (793bp). Cyp2c66 (613bp). *. *. *. *. *. *. Retnl. g. (. 738bp. ). Ccr3 (730bp). Analysed CpG. *. Not analysed CpG. *. *. *. *. *. *. *. *. *. *. *. *. *. *. *. :. DNA . methylation. I. Requirements for epigenetic materials. Need to be . transmitted faithfully . during mitosis and meiosis (possibly along with DNA). -> . cell need to have . maintenance mechanisms similar to semi-conservative mechanism of DNA replication. in vitro . and . in vivo . toxicity of chitosan-pDNA . polyplexes. Kae Amaraporn. The Department of Pharmaceutics and Translational Therapeutics. College of Pharmacy. 1. Gene delivery to lung. The transmission of DNA encoding for therapeutic gene or protein into the target cells for prevention or treatment of disease. hydroxide nanoparticles . conjugated with . CpG. to polarise immune responses from Th2 to Th1 bias. Shiyu Yan, Bing Zhang, Wenyi Gu, . Zhi Ping (Gordon) Xu. Australian Institute for Bioengineering and Nanotechnology. Gene regulation. Genomes . usually contain several . thousands of . different genes. .. Some . of the . gene products . are required by the cell under all growth conditions and are called . housekeeping genes. Level. Jeffrey W. Fergus, . Auburn University. Clarissa . Yablinsky. , . Los . Alamos National . Laboratory. Juan . Pablo Escobedo-Diaz, . University . of New South Wales Canberra. 2/15/2017. 1. TMS 101: Participating Above the Presenter Level. Proposed an efficient exosome-based tumor antigens-adjuvant co-delivery system:. Genetically engineered tumor cell-derived exosomes: . Endogenous tumor antigens. Immunostimulatory. . CpG. DNA. Source cells (for exosome): murine melanoma B16BL6. Vesto. DNA M. ethylation. Q. uantification. What is DNA Methylation?. How do we know if we . have methylated DNA?. Why do we care?. D. ata. Sanger sequence?. Simulate toy sequences by randomly changing C . λ. -. DNA . . Objective: To represent de novo methylation of DNA. Model. for epigenetic changes in DNA. Methylase. DNA. Cytosin. Me. Internship. . epigenetic. Methyltransferases transfer a methyl group to the DNA. J. Mol. Biol. (1987) 196, 261-282 M. Gardiner-Garden’ and M. Frommer1v2 ‘The Kanematsu Laboratories, Royal Prince Alfred Hospital Missenden Road, Camperdown N.S. W. 2050, Australia 2CSIR0 . has the following financial relationships to disclose:. List relationships. Name of . Chair/Presenter/Discussant. . has no relevant financial relationships to disclose. . I. Requirements for epigenetic materials. Need to be . transmitted faithfully . during mitosis and meiosis (possibly along with DNA). -> . cell need to have . maintenance mechanisms similar to semi-conservative mechanism of DNA replication. Angus Cheung | Sunny Sun | Eden Sorrell | Raymond . Franczuk. Asper School of Business. Presenting to: . Fidji. Simo of Instacart. Niche to necessity. Understanding the challenge. Sustainable profitability.