PPT-Human genetic variation: Recombination, rare variants and s

Gil McVean There are no new questions in population genetics only new types of data Genome sequences of entire populations Data with linkage to deep phenotype information Data from multiple species. Jeff Barrett. What are the goals of disease genetics?. For a given disease, we would like to:. Predict if someone will get sick, how bad it will be, and what treatment will work.. Test hypotheses about relationships to other diseases and traits.. Venessa. Williams. Hai Tran. Myles Everett. Alex . Detlefsen. Bio 1510-A Group A39. September 13, 2012. Introduction. Little known about genome sequences of Africans. Common ancestors. 1000 Genomes Project used new technology to view whole genome sequences. Professor . Department of . Epidemiology and. Genetic Epidemiology Research Institute. University . of . California, Irvine. . Irvine, CA. kedward1@uci.edu. What is old is new. Rare Variants. This session. Liz Cirulli. Assistant Research Professor. Duke Center for Applied Genomics and Precision Medicine (CAGPM). 4/27/15. Advantages to studying healthy variation. Most “healthy” traits not studied genetically at all. You can compare dogs of every breed imaginable! . There is an enormous range of characteristics that are the result of . genetic variation. . . The differences among breeds of dogs are so great that someone might think that many of these breeds are different species. . You can compare dogs of every breed imaginable! . There is an enormous range of characteristics that are the result of . genetic variation. . . The differences among breeds of dogs are so great that someone might think that many of these breeds are different species. . Implications for . Germline. Editing. Human Diseases and Traits. Rare, . Mendelian. Cystic fibrosis, . Huntington Disease,. Diastrophic Dysplasia . …. Common, . polygenic. Heart disease, Alzheimer’s. ANGGOTA KELOMPOK. SRI YUNIARTININGSIH (P2BA10009). YAYUK SUGIYARTI (P2BA10025). IHDA SYFAI (P2BA10010). Origins of Genetic Variation Among Offspring. The behavior of chromosomes during meiosis and fertilization is responsible for most of the variation that arises in each generation. BMI/CS 776 . www.biostat.wisc.edu/bmi776/. Spring 2022. Daifeng. Wang. daifeng.wang@wisc.edu. These slides, excluding third-party material, are licensed under . CC BY-NC 4.0. . by Mark Craven, Colin Dewey, Anthony . Independent Assortment & Linkage. Genetic & Physical Maps. Lecture 1- Genetics. Madan K. Bhattacharyya, Ph.D.. Professor, Iowa State University. Adjunct Prof., Assam Agricultural University. mbhattac@iastate.edu. American Journal of Obstetrics & Gynecology 2015. Alastair MacLennan. , Emeritus Professor Obstetrics & Gynaecology,. Suzanna Thompson. , . Paediatric. Neurology,. Jozef Gecz. , Professor of Neurogenetics Research. As an alternative, Speakman has putforward a non-adaptive scenariothe drifty gene hypothesis.According to this idea, genetic drift— the change ofgenefrequencies due to random, non-selective proce Discovery. Genetic linkage was first discovered by the British. . geneticists William Bateson, Edith Rebecca Saunders and Reginald Punnett. . shortly after Mendel's laws were rediscovered. The understanding of genetic linkage was expanded by the work of Thomas Hunt Morgan. . Pairs of allelic genes may exchange chromosomal locations( genetic elements can move, both between chromosomes and within them.) by a process known as genetic recombination.. Homologous recombination .