PPT-Aplastic anaemia and bone marrow failure

Pancytopenia Pancytopenia is a reduction in the blood count of all the major cell lines red cells white cells and platelets It has several causes which can be broadly divided into decreased bone marrow . By. . SOMESHWAR.K. M.PHARM.. II - SEMESTER . . . Department of Pharmaceutics. University College of Pharmaceutical Sciences,. KAKATIYA UNIVERSITY. Anaemia. Prof. Aziz-ur-Rehman. Introduction. Very common problem. Subtle or no symptoms, usually incidental finding. Various causes; ID is the commonest. Simple iron replacement is not the solution. Investigate before starting treatment. Agenda. 1.. 2.. 3.. 4.. Introduction. Introduction to Aplastic Anemia, its risk factors and epidemiolog. y . Mechanism . Look at the pathophysiology and the diagnosis of the disease . Next Steps. Take a closer look at research that is being done . Department of Pathology and Laboratory Medicine. Located 2-3655. Hours of Operation: . 8am-6pm M-F . 8am-5pm Saturday. . Follow a . Bone. Marrow from collection to diagnosis. Laboratory. Testing. Normal physiological values. Neonates: 137 – 200 g/L (as high as 22 g/. dL. ). 3 months: 95 – 145 (physiological drop: “fetal” RBC dying off faster than “adult” RBC can be made). 1.5 years: 105 – 104 (mild hypochromic microcytic picture between 6m and 6y). Dr. M. Sabloff. Director of the Leukemia Program at the Ottawa Hospital. October 13. th. 2018. Disclosures . Objectives. Aplastic anemia. Epidemiology. Treatment options. P. NH. Epidemiology. Treatment. Abeer. . Anwer. Ahmed. Objectives. Explain background, definition . and etiology of . hypochromic. . anemias. Outline diagnostic algorithm of . . hypochromic. . anemias. Identify key laboratory findings to diagnose . (PNH). PNH. is . a rare, acquired, . clonal. disorder of marrow stem cells . in which . there . is. . deficient synthesis of . the . glycosyl-phosphatidyl-inositol. (GPI. ) anchor, a structure that attaches . - tion (Figure 1). Skeletal aging is characterized as a gradual loss of bone mass due to an excess of bone resorption that is not matched by new bone formation. There are two major types of bone . Shekhar. . . . Asstt. Professor. Veterinary Medicine . UNIT-1. Definition and Etiology. Anaemia- Classification. . Anemia. is classified as. Regenerative. Non regenerative. . Part 2. Wendy Blount, DVM. Slide Preparation. Pipette flecks out of the petri dish and put on glass slides immediately. Elevate one end of the slide to let extra blood run . off. Slide Preparation. Pipette flecks out of the petri dish and put on glass slides immediately. One of the most common . anaemias. occurs in patients with . a variety of chronic inflammatory and malignant diseases. The characteristic features. 1 . Normochromic. , . normocytic. or mildly . hypochromic. MD. ASSTT. PROFESSOR. DEPTT. OF MEDICINE. Aplastic. anemia is . pancytopenia. with bone marrow . hypocellularity. .. M. en and women are affected with equal frequency.. A. ge distribution is biphasic, with the major peak in the teens and twenties and a second rise in older adults.. Anna Koget, D.O. . Aplastic Anemia . An . acquired. stem cell disorder . Idiopathic (unknown etiology) in 70% of the cases . Diagnosis of exclusion . Important to differentiate from other causes of Bone Marrow Failure .