PPT-The covalent targeting of cysteine residues in drug discovery and its application to the

Tagrisso TM Richard A Ward Medicinal Chemistry Oncology IMED Biotech Unit AstraZeneca Cambridge UK BigChem Training School Gothenburg May 2019 Potential gains in Potency Selectivity. By. . SOMESHWAR.K. M.PHARM.. II - SEMESTER . . . Department of Pharmaceutics. University College of Pharmaceutical Sciences,. KAKATIYA UNIVERSITY. Chapter 9 ~ most compounds, including those in living organisms, are covalently bonded. What You’ll Learn. I will analyze the nature of a covalent bond. I will name covalently bonded groups of atoms. Vi Do. Basic Info & Structure . . . Nonessential, hydrophobic . α. -amino acid. Characterized as a . non-polar. amino acid. Has . thiol. group containing sulfur. Molecular formula is . C. Including Naming. Note: We likely won’t make it to covalent nomenclature, this is the one students find FAR easier than ionic. Please refer to the videos and naming hand out for help with this, and as always office hours, discussions, and . Dr. G. SARATH CHANDRA, . Ph.D. Professor and Head. Pharmacovigilance Laboratory for Animal Feed and Food Safety. Directorate of Centre for Animal Health Studies. Tamil Nadu Veterinary and Animal Sciences University. Ball-and-stick model. Molecular . Compounds. OBJECTIVES:. Distinguish. between the melting points and boiling points of . molecular. compounds and . ionic. compounds.. Molecular . Compounds. OBJECTIVES:.  . 1) . SeF. 6. . . ________________________________________.  . 2) . TeO. 3 . . ________________________________________.  . 3) . H. 2. O. . . ________________________________________.  . Bonding. Bonding models for methane, CH. 4. . Models are NOT reality. Each has its own strengths and limitations.. Ga . Standards. Students know . atoms combine to form molecules by sharing electrons to form covalent or metallic bonds or by exchanging electrons to form ionic bonds.. Covalent bonding. Ionic bonding. Ionic Bonding. Bonding as you’ve never imagined it. http://www.youtube.com/watch?v=BCYrNU-7SfA. Objectives. To consider the features of ionic and covalent bonds, and the compounds they make. Types of bonds. Ionic bonding. results from electrostatic attractions among ions, which are formed by the . transfer. of one or more electrons from one atom to another.. Covalent bonding. results from . What do these images have in common?. How are they different?. What do you know about the uses of graphite and carbon?. Learning questions. What are giant covalent molecules?. How are they similar/ different from each other?. Covalent Compounds. Formed between two non-metals. Valence electrons are shared between atoms. Binary Covalent Compounds. Contain just two different types of non-metal elements. Some Different Rules. Covalent bonds . result from the . sharing . of electrons. between two atoms.. A covalent bond is a . two-electron bond . in which the bonding atoms share valence electrons.. A . molecule . is a discrete group of atoms held together by covalent bonds.. 6.2. Molecules. Molecules – a neutral group of atoms held together by . covalent. bonds. Molecular compound – a . cmpd. whose simplest units are molecules. Chemical formula – indicates relative # of atoms of each kind in a chemical compound by using atomic symbols & subscripts.