Williamson Ether Synthesis

96 Ethers are prepared by S N 2 reactions Ethers can be prepared by the reaction of an alkoxide with a primary haloalkane or sulfonate ester under S N 2 conditions The parent alcohol of the alkoxide can be used as the solvent however other polar solvents are often better such as DMSO dimethyl sulfoxide or HMPA hexamethylphosphoric triamide

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